abstract：BACKGROUND AND AIMS:Distal renal tubular acidosis (dRTA) is characterized by a reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis. Mutations in the SLC4A1 gene have been found to cause either autosomal dominant (AD) or autosomal recessive (AR)...

journal_title：Archives of medical research

authors： Zhang Z,Liu KX,He JW,Fu WZ,Yue H,Zhang H,Zhang CQ,Zhang ZL

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Vardenafil has been found to be potent in pulmonary hypertension; however, the underlying mechanisms remain poorly understood. To address this issue, we investigated the underlying mechanisms of vardenafil in the contribution of Ca(2+) signaling and mobilization in modifying vasoconstriction of pulm...

journal_title：Archives of medical research

authors： Chen WS,Li XQ,Cao W,Xiao X,Dong L,Zhang JZ

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The catechol-O-methyltransferase (COMT) gene is a potential candidate in altering risk for preeclampsia due to the important enzymatic effects in the metabolism of steroid hormones. It contains a non-synonymous G-A base change at codon 158 in the membrane bound isoform, which leads to a valine-to-me...

journal_title：Archives of medical research

authors： Liang S,Liu X,Fan P,Liu R,Zhang J,He G,Liu Y,Bai H

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Hypophosphatasia is a genetic disorder characterized by defective bone and tooth mineralization and a deficiency of serum and bone alkaline phosphatase activity. To date, few studies have identified gene mutations in Chinese patients with hypophosphatasia. We sought to characterize the clinical mani...

journal_title：Archives of medical research

authors： Zhang H,Ke YH,Wang C,Yue H,Hu WW,Gu JM,Zhang ZL

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Helicobacter pylori is the most common etiological factor of chronic infection worldwide. It has also been found in human dental plaques, mouth, saliva, tonsils and adenoid tissue, medial ear or nasal polyps and sinuses mucosa, as well in several benign and malignant lesions of the larynx and pharyn...

journal_title：Archives of medical research

authors： Burduk PK,Kaczmarek A,Budzynska A,Kazmierczak W,Gospodarek E

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Umbilical cord blood (UCB) has been identified as a good source of hematopoietic and nonhematopoietic stem cells that can be easily isolated. In the present study we investigated the possibility of whether stem cells in mononuclear UCB grown under defined conditions can produce progeny with neural p...

journal_title：Archives of medical research

authors： Slovinska L,Novotna I,Kubes M,Radonak J,Jergova S,Cigankova V,Rosocha J,Cizkova D

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:This study was carried out to assess and investigate the prevalence of overweight and obesity among preschool-age children living in northeast China using the World Health Organization (WHO), International Obesity Task Force (IOTF) and Centers for Disease Control and Prevention (CDC) standard criter...

journal_title：Archives of medical research

authors： Ma YN,Chen T,Wang D,Liu MM,He QC,Dong GH

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:In previous studies, the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) was shown to be associated with both lipid metabolism and longevity. We examined whether the polymorphism continued to be associated with abnormal levels of serum lipid/lipoprotein amon...

journal_title：Archives of medical research

authors： Chang-Quan H,Hui W,Qing-Xiu L,Gang C

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AG...

journal_title：Archives of medical research

authors： Su XD,Li SS,Tian YQ,Zhang ZY,Zhang GZ,Wang LX

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Supplementation with n3 long-chain polyunsaturated fatty acids (n3-LCPUFA) appears to affect body weight, adipokines, and insulin resistance (IR) in obese individuals. However, it is unclear whether the effect on IR is independent of weight loss and if the same effect is observed in children. We und...

journal_title：Archives of medical research

authors： López-Alarcón M,Martínez-Coronado A,Velarde-Castro O,Rendón-Macías E,Fernández J

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Genome-wide association studies recently found IGF2BP2 rs4402960 polymorphism associated with enhanced risk of type 2 diabetes mellitus (T2DM). Numerous studies have been published to replicate the association. However, results were inconsistent and inconclusive. To clarify the relationship of IGF2B...

journal_title：Archives of medical research

authors： Jia H,Yu L,Jiang Z,Ji Q

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND AND AIMS:N-acetyltransferase 2 (NAT2) is a drug-metabolizing enzyme, which is genetically variable in human populations. Polymorphisms in the NAT2 gene have been associated with drug efficacy and toxicity as well as disease susceptibility. Recently, an association of NAT2 gene variation with risk of type 2 d...

journal_title：Archives of medical research

authors： Semiz S,Dujic T,Ostanek B,Velija-Asimi Z,Prnjavorac B,Bego T,Malenica M,Mlinar B,Heljic B,Marc J,Causevic A

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AND AIMS:CTLA-4 exon-1 +49A>G polymorphisms have been reported to influence the risk for primary biliary cirrhosis in many studies; however, the results still remain controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between CTLA-4 exon-1 +49A>G ...

journal_title：Archives of medical research

authors： Huang Q,Shao F,Wang C,Qiu LJ,Hu YG,Yu JH

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Cervical cancer is a common neoplastic disease affecting women worldwide. Expression of human papillomavirus type 16 (HPV-16) E6/E7 genes is frequently associated with cervical cancer, representing ideal targets for diagnostic and therapeutic strategies. Aptamers are oligonucleotide ligands capable ...

journal_title：Archives of medical research

authors： Toscano-Garibay JD,Benítez-Hess ML,Alvarez-Salas LM

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Extended-spectrum β-lactamase (ESBLs) production is still the most frequent mechanism of resistance to cephalosporins in gram-negative bacteria. The aim of the study was to identify the types of ESBL-producing Enterobacteriaceae clinical isolates causing nosocomial infections in Mexico. METHODS:ESB...

journal_title：Archives of medical research

authors： Silva-Sanchez J,Garza-Ramos JU,Reyna-Flores F,Sánchez-Perez A,Rojas-Moreno T,Andrade-Almaraz V,Pastrana J,Castro-Romero JI,Vinuesa P,Barrios H,Cervantes C

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:HTLV-I-transformed T cells secrete biologically active forms of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (b-FGF). In addition, HTLV-I-transformed cells have a high capacity of adhesion to endothelial cells. METHODS:We measured the circulating endothelial progenit...

journal_title：Archives of medical research

authors： Meireles AL,Hallack Neto AE,Costa Rde O,Pereira J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We undertook this study to investigate the association between CT perfusion characteristics and differentiation grade in lung cancer, as well as the pathological basis of this association. METHODS:Seventy three patients received CT perfusion scan and pathological biopsy, and 30 of them were availab...

journal_title：Archives of medical research

authors： Xiong Z,Liu JK,Hu CP,Zhou H,Zhou ML,Chen W

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND AIMS:This study is concerned with the expressions of growth-associated protein-43 (GAP-43) mRNA and protein in the anterior horn of the spinal cord after brachial plexus injury. METHODS:Animals were killed 1, 7, 14 days after injury and were divided into three injury groups: group 1, right C(7) ventral ...

journal_title：Archives of medical research

authors： Chen LJ,Ren YH,Liu L,Zhang XQ,Zhao Y,Wu WT,Li F

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The risks of insulin resistance and accelerated atherosclerosis are increased in chronic inflammatory diseases including rheumatoid arthritis (RA). Adipo-(cyto)kines are associated with insulin resistance, atherosclerosis and inflammation. This study aimed to determine serum adiponectin and vaspin l...

journal_title：Archives of medical research

authors： Ozgen M,Koca SS,Dagli N,Balin M,Ustundag B,Isik A

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Occult hepatitis B infection (OBI) is defined as a form of hepatitis in which, despite absence of detectable HBsAg, HBV-DNA is present in peripheral blood of patients. The main aim of this study was to determine an association between polymorphisms in +801 of CXCL12 (SDF-1α) and its serum level in OBI patien...

journal_title：Archives of medical research

authors： Hassanshahi G,Arababadi MK,Khoramdelazad H,Yaghini N,Zarandi ER

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND AIMS:This study was designed to identify susceptibility to insulin resistance and the association of serum resistin and adiponectin with insulin resistance in patients with Behçet's disease (BD). Also, we identify risk determinants for insulin resistance in BD patients. METHODS:The study population cons...

journal_title：Archives of medical research

authors： Kim SK,Choe JY,Park SH,Lee SW,Lee GH,Chung WT

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The etiology of atherosclerosis is multifactorial. Genetic and environmental factors are involved in the development of atherosclerosis. Human arylamine N-acetyltransferase 2 (NAT2) is an important metabolizing enzyme that exhibits genetic polymorphisms and modifies individual response and/or toxici...

journal_title：Archives of medical research

authors： Khelil M,Zenati A,Makrelouf M,Otmane A,Tayebi B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Although sporadic cases of cancer in patients with fragile X syndrome (FXS) have been reported, extensive studies carried out in Denmark and Finland concluded that cancer incidence in these patients is lower than in the general population. On the other hand, the FMR1 protein, which is involved in th...

journal_title：Archives of medical research

authors： Rosales-Reynoso MA,Ochoa-Hernández AB,Aguilar-Lemarroy A,Jave-Suárez LF,Troyo-Sanromán R,Barros-Núñez P

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Peroxisome proliferator activated receptor-gamma (PPARgamma) and lipoprotein lipase (LPL) genes are important in pathways of triglyceride metabolism, insulin resistance and adipogenesis. We hypothesized that polymorphisms of PPARgamma Pro12Ala, LPL HindIII and LPL Ser447X influence severity of coron...

journal_title：Archives of medical research

authors： AshokKumar M,Veera Subhashini NG,Kanthimathi S,SaiBabu R,Ramesh A,Cherian KM,Emmanuel C

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Further cases of novel influenza A (H1N1) outbreak are expected in the coming months. Vaccination has been proven to be essential to control a pandemic of influenza; therefore, considerable efforts and resources have been devoted to develop a vaccine against the influenza A (H1N1) virus. With the cu...

journal_title：Archives of medical research

authors： Esteves-Jaramillo A,Omer SB,Gonzalez-Diaz E,Salmon DA,Hixson B,Navarro F,Kawa-Karasik S,Frew P,Morfin-Otero R,Rodriguez-Noriega E,Ramirez Y,Rosas A,Acosta E,Varela-Badillo V,Del Rio C

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF), an important regulator of angiogenesis and vascular permeability, is involved in various steps of many malignancies. Gene polymorphisms within the gene encoding VEGF have been shown to be independently associated with an adverse outcome in various malignancies inclu...

journal_title：Archives of medical research

authors： Wu LM,Xie HY,Zhou L,Yang Z,Zhang F,Zheng SS

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Previous published data have implicated TP53 codon 72 polymorphisms as risk factors for various cancers. Growing bodies of studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present...

journal_title：Archives of medical research

authors： Zhuo XL,Li Q,Zhou Y,Cai L,Xiang ZL,Yuan W,Zhang XY

更新日期：2009-10-01 00:00:00

abstract：:In contrast to the prophylactic HPV vaccines that exhibit great promise in reducing the burden of cervical cancer, there is limited progress towards the development of immune therapeutic strategies that would help those women who are already infected with high-risk HPV and do not benefit from the current vaccines. The...

journal_title：Archives of medical research

authors： Gissmann L,Nieto K

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND AIM:Oxalobacter formigenes is an intestinal bacterium that utilizes oxalate as the only source of energy. It has been suggested that the lack of colonization with this organism may be a risk factor for calcium oxalate urolithiasis. Because this problem was not investigated in pediatric stone formers, we ...

journal_title：Archives of medical research

authors： Sikora P,Niedźwiadek J,Mazur E,Paluch-Oleś J,Zajaczkowska M,Kozioł-Montewka M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:It remains unclear whether U50488H (a selective kappa-opioid receptor agonist) produces anti-apoptotic effect during ischemia and reperfusion (I/R). Therefore, the effect of U50488H on myocardial apoptosis was investigated in the present study. METHODS:Rats were subjected to 45min coronary artery o...

journal_title：Archives of medical research

authors： Rong F,Peng Z,Ye MX,Zhang QY,Zhao Y,Zhang SM,Guo HT,Hui B,Wang YM,Liang C,Gu CH,Tao C,Cui Q,Yu SQ,Yi DH,Pei JM

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. Several studies have been conducted on the association of TP53 codon 72 polymorphisms with susceptibility to nasopharyngeal carcinoma (NPC) and have yielded inconclusive results. The aim of the present ...

journal_title：Archives of medical research

authors： Zhuo XL,Cai L,Xiang ZL,Zhuo WL,Wang Y,Zhang XY

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The cardiac regulator of G-protein signaling 2 (RGS2) negatively regulates G-protein-coupled receptor signaling. The C1114G polymorphism reduces RGS2 gene expression. This molecular disorder may be one of the important factors influencing progress of neurally mediated syncope. The aim of the study w...

journal_title：Archives of medical research

authors： Lelonek M,Pietrucha T,Matyjaszczyk M,Goch JH

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Metabolic acidosis (MA) is a frequent and serious complication in HIV-infected patients. The aim of the study is to compare patients with and without MA associated with HIV. METHODS:Patients were retrospectively studied involving all HIV-infected patients with blood gas analysis performed during ho...

journal_title：Archives of medical research

authors： Daher EF,Cezar LC,Silva GB Jr,Lima RS,Damasceno LS,Lopes EB,Nunes FR,Mota RS,Libório AB

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Preimplantation genetic diagnosis (PGD) of monogenic autosomal hereditary disorders following assisted conception usually involves the removal of one or two blastomeres from preimplantation embryos. However, the amount of DNA from a single blastomere is insufficient to amplify the region of interest. Hence, ...

journal_title：Archives of medical research

authors： Nasri NW,Jamal AR,Abdullah NC,Razi ZR,Mokhtar NM

更新日期：2009-01-01 00:00:00

abstract：:Systems biology and the Herbalome Project have good prospects if the specific episteme-method approach of traditional Chinese medicine (TCM) is taken into serious consideration. TCM takes advantage of a specific holistic method, which is based on the episteme method approach derived from the conceptions of unceasing m...

journal_title：Archives of medical research

authors： Liang T

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Previous studies demonstrated that (99m)Tc-labeled-ubiquicidin 29-41 ((99m)Tc-UBI 29-41) imaging is an accurate method for detection of bacterial infections. This study was conducted to evaluate the clinical use of (99m)Tc-UBI 29-41 for detection of mediastinitis after cardiac surgery. METHODS:Thirteen pati...

journal_title：Archives of medical research

authors： Vallejo E,Martinez I,Tejero A,Hernandez S,Jimenez L,Bialostozky D,Sanchez G,Ilarraza H,Ferro-Flores G

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:A recent revelation about increased susceptibility to HIV by use of nonoxynol-9 (N-9) has called for identification of novel molecules with potent sperm-attenuating activity and lower side-effect profile, as suitable alternatives. The present study was designed to investigate spermicidal activity in Bohadsch...

journal_title：Archives of medical research

authors： Lakshmi V,Saxena A,Mishra SK,Raghubir R,Srivastava MN,Jain RK,Maikhuri JP,Gupta G

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) has been shown to improve the clinical status and survival in congestive heart failure (CHF) patients, but little is known about its influence on neurohormonal profile. METHODS:Heart failure patients treated with CRT for moderate/severe heart failure were studied with...

journal_title：Archives of medical research

authors： Menardi E,Vado A,Rossetti G,Racca E,Conte E,Deorsola A,Bobbio M,Feola M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Gamma-irradiation of platelet concentrates may inactive contaminated lymphocytes and subsequently inhibit the synthesis of cytokine in platelet during storage. The aim of this study was to determine the effect of gamma-irradiation on the production of IL-8 and lymphocyte proliferation isolated from random do...

journal_title：Archives of medical research

authors： Pourfathollah AA,Shaiegan M,Namiri M,Babae GR

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Iron deficiency is the most common cause of anemia in children. Recently there has been evidence to suggest a relationship between Helicobacter pylori gastritis and iron deficiency anemia. Because both H. pylori infection and iron-deficiency anemia are common in children, we studied any correlation between H...

journal_title：Archives of medical research

authors： Haghi-Ashtiani MT,Monajemzadeh M,Motamed F,Mahjoub F,Sharifan M,Shahsiah R,Kashef N

更新日期：2008-07-01 00:00:00